Figure 1. Clinical presentation and histopathology of CIN and CIS.

Case 1 (CIN): Elevated mass with frond-liked vascular projection located at nasal limbus (dash line) (A); dysplastic change involving almost full thickness of epithelial layer with intact basement membrane (B). Case 2 (CIS): Papilliform mass with typical hairpin vascular configuration located at temporal bulbar conjunctiva (C); dysplastic cells extending to all of the epithelial layers, with intact basement membrane (D). Case 3 (CIS): Large papilliform mass located at nasal limbus with adjacent corneal invasion (E); full thickness of epithelium showing dysplastic configuration with multiple neoplastic vascularization (arrow), corresponding with clinical findings (F). Case 4 (CIS): Multifocal nodular masses located at nasal bulbar conjunctiva; some pigmentation (arrows) and conjuctival fibrosis (arrow head) were observed (G); multiple dysplastic epithelial lobules were found, with no basement membrane invasion (H). Scale bars = 100 μm.