Table 4. Heterogeneity-analysis results.
| Comparisons | B vs A |
BB vs AA |
BB vs AA+AB |
BB+AB vs AA |
AB vs AA |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| I2 | P | EM | I2 | P | EM | I2 | P | EM | I2 | P | EM | I2 | P | EM | |
| rs2275913 | |||||||||||||||
| Overall | 61% | <0.001 | R | 64% | <0.001 | R | 70% | <0.001 | R | 60% | <0.001 | R | 62% | <0.001 | R |
| HWE | |||||||||||||||
| Yes | 58% | 0.001 | R | 57% | 0.001 | R | 60% | <0.001 | R | 43% | 0.02 | R | 39% | 0.04 | R |
| Ethnicity | |||||||||||||||
| Asian | 62% | <0.001 | R | 63% | <0.001 | R | 68% | <0.001 | R | 62% | <0.001 | R | 60% | <0.001 | R |
| Caucasian | 68% | 0.01 | R | 72% | 0.007 | R | 80% | 0.001 | R | 58% | 0.05 | R | 70% | 0.009 | R |
| Cancer type | |||||||||||||||
| GC | 74% | <0.001 | R | 75% | <0.001 | R | 79% | <0.001 | R | 73% | <0.001 | R | 71% | <0.001 | R |
| CRC | 84% | 0.01 | R | 0% | 0.48 | F | 0% | 0.61 | F | 74% | 0.05 | R | 14% | 0.28 | F |
| CC | 0% | 0.45 | F | 0% | 0.40 | F | 0% | 0.47 | F | 0% | 0.51 | F | 0% | 0.51 | F |
| HCC | 0% | 0.93 | F | 0% | 0.88 | F | 0% | 0.56 | F | 0% | 0.43 | F | 8% | 0.30 | F |
| rs763780 | |||||||||||||||
| Overall | 68% | <0.001 | R | 0% | 0.79 | F | 0% | 0.79 | F | 64% | <0.001 | R | 57% | 0.001 | R |
| HWE | |||||||||||||||
| Yes | 68% | <0.001 | R | 0% | 0.79 | F | 0% | 0.82 | F | 66% | <0.001 | R | 61% | 0.002 | R |
| Ethnicity | |||||||||||||||
| Asian | 37% | 0.12 | F | 0% | 0.94 | F | 0% | 0.93 | F | 43% | 0.08 | R | 44% | 0.08 | R |
| Caucasian | 78% | 0.003 | R | 17% | 0.30 | F | 5% | 0.35 | F | 72% | 0.02 | R | 59% | 0.06 | R |
| Cancer type | |||||||||||||||
| GC | 31% | 0.17 | F | 6% | 0.79 | F | 0% | 0.72 | F | 10% | 0.36 | F | 0% | 0.48 | F |
| CRC | 66% | 0.09 | R | – | – | – | – | – | – | 67% | 0.08 | R | 67% | 0.08 | R |
A: the major allele; B: the minor allele; EM: Effects model; F: fixed effects model; R: random effects model; GC: Gastric cancer; CRC: colorectal cancer; CC: cervical cancer; HCC: hepatocellular carcinoma.