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. 2016 Feb 1;7:54. doi: 10.3389/fmicb.2016.00054

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Copyright © 2016 Purushothaman, Dabral, Gupta, Sarkar and Verma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of KSHV latent DNA replication initiation. KSHV genomes replicate once per cell cycle during latent DNA replication and are perpetually segregated into the daughter cells. KSHV heavily depend on host cellular machinery for its latent DNA replication. Latent DNA replication is initiated by the direct association of LANA to LBS1/2 within the origin of latent DNA replication, ori-P, thereby triggering the recruitment various components of replication licensing and pre-replication complex (pre-RC) proteins to ori-P. The sequential assembly of pre-replication complex, including origin recognition complex (ORC), cell division cycle (Cdc6), Cdt1 and minichromosome maintenance proteins (MCM) within the nuclear matrix region initiate KSHV latent DNA replication.