Figure 5. Active promoter with local remodeling activity.

(a) Promoter-state distribution for selected Pho4p binding rate, r_onp ≈ 0.3–0.6 × k₀s⁻¹, that are the best fit with the experimental data, CRBact (triangles). CRBact data points were obtained from transcriptionally active PHO4 pho80Δ cells where Pho80p has lost its phosphorylation activity⁴⁴. (b,c) are the corresponding mRNA distributions and nucleosome occupancies. In (b), grey-shade denotes the percentage of OFF cells, otherwise ON cells. Green curve in (c) is the occupancy in the repressed state. The data presented here are for V_eff = −7k_BT and LRA, h = 21k_BT.