Table 1. Overview of study data sets.
| Data | Age, years | % Male | Brain region | NGWAS | Ncis-eQTL | Reference | Public availability |
|---|---|---|---|---|---|---|---|
| Study 1 | 86±8.0 (55, 105) | 38 | CRBLM | 59 | NA | Lunnon et al,52 | GSE59685 |
| Study 2 | 48.0±23.2 (16, 96) | 70 | CRBLM | 112 | 144 | Gibbs et al,43 | GSE15745GSE36192 |
| FCTX | — | 144 | |||||
| PONS | — | 143 | |||||
| TCTX | — | 145 | |||||
| Study 3 | 44.3±9.6 (19, 68) | 63 | CRBLM | 147 | 130 | Zhang et al,53 | GSE35978GSE38873 |
| Study 4 | 64.4±17.4 (25, 96) | 61 | CRBLM | 36 | NA | Pidsley et al,54 | GSE61431 |
| Study 5 | 52.3±29.8 (1, 102) | 66 | CRBLM | 201 | 219 | Hernandez et al,55 | GSE36192GSE31694 |
| FCTX | — | 218 | |||||
| Study 6 | 30.7±10.8 (15, 65) | 81 | Neuron | — | 81 | Di Narzo et al,56 | NA |
CRBLM, cerebellum; FCTX, frontal cortex; NA, not available; Ncis-eQTL, number of participants passing QC available for cis-eQTL analysis; NGWAS, number of participants passing QC available for GWAS analysis; PONS, pons; TCTX, temporal cortex.
— denotes the brain region data were not used for GWAS.
The first five studies involved a total of n=555 individuals that were used in our GWAS of cerebellar epigenetic age acceleration. Study 6 was used for a cis-expression QTL analysis in sorted neurons.