Table 1. The basic demographics and clinical assessment scores of the patients (n = 41).
| CDR 0 (n = 9) | CDR 0.5 (n = 13) | CDR 1 (n = 11) | Depression (n = 8) | P-value† | |
|---|---|---|---|---|---|
| Age, median (range)* | 63 (50–74) | 68 (56–79) | 69 (57–80) | 61.5 (56–66) | 0.039 |
| Sex (M:F) | 4:5 | 4:9 | 6:5 | 2:6 | |
| MMSE-K | 28.3 ± 0.7 | 26.8 ± 0.4 | 23.8 ± 0.6a,d | 25.1 ± 1.4 | 0.001 |
| CDR | 0 | 0.5 | 1 | 0.6 ± 0.2 | |
| ADAS-Cog-K | 8.4 ± 1.4 | 11.2 ± 1.1 | 16.0 ± 2.4c | 14.6 ± 3.2 | 0.031 |
| BDI-II | 5.2 ± 1.8 | 11.1 ± 1.4c | 9.3 ± 2.0 | 29.4 ± 2.4a,d,f | <0.001 |
| KVSS | 24.2 ± 1.1 | 23.6 ± 1.6 | 22.6 ± 0.9 | 21.9 ± 2.6 | 0.750 |
| Relative miR-206 level‡ | 1 | 7.8 ± 1.9b | 41.5 ± 6.4a,d | 1.2 ± 0.5e,f | <0.001 |
*Data presented as the median (range).
†The Kruskal-Wallis test was performed.
‡The relative miR-206 levels are divided by the mean value for the CDR 0 group.
aP < 0.001 vs. control.
bP < 0.01 vs. control.
cP < 0.05 vs. control.
dP < 0.001 vs. CDR 0.5.
eP < 0.01 vs. CDR 0.5.
fP < 0.001 vs. CDR 1.
Values are presented as the mean ± standard error of the mean (SEM). Abbreviations: CDR: clinical dementia rating, M: male, F: female, MMSE-K: Korean version of the Mini-Mental State Examination, ADAS-Cog-K: Korean version of the Alzheimer’s Disease Assessment Scale-cognitive subscale, BDI-II: Beck Depression Inventory-II.