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. 2016 Feb 4;6:20489. doi: 10.1038/srep20489

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(A) Two putative binding sites of miR-101 on the 3′UTR of VHL. (B) Suppression of the luciferase activity by miR-101. (C) Suppression of the luciferase activity by miR-101 in a dose dependent manner. (D) anti-miR-101 increased the luciferase activity in cells with miR-101 over-expression. (E) Effect of miR-101 on the luciferase activity of VHL-3′UTR, VHL-3′UTR-m1, VHL-3′UTR-m2 and VHL-3′UTR-dm. (F) HIF1α, VEGFA, VHL level changes in MCF-7 and MDA-MB-231 cells with or without miR-101 over-expression by western blot. (G) mRNA level changes of VHL in MCF-7 and MDA-MB-231 cells with or without miR-101 over-expression by qPCR. Data were analyzed using Student’s t-test. *P < 0.05; **P < 0.01; ***P < 0.001.