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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Cancer Res. 2015 Dec 4;76(3):724–735. doi: 10.1158/0008-5472.CAN-15-0701-T

Figure 3.

Figure 3

Structural analysis of MLK4-Y330H mutant. A, Time lapse images highlight the changes occurring within the phenylalanine of the DFG motif (i), residues of the GxGxxG motif (ii) and HRD motif (iii) of MLK4-Y330H (orange) and WT (black) over the course of the simulation. Movement determined by the average RMSD for each residue within these structures. Values are representative of three independent simulations. Error bars indicate ±SEM, * p<0.05. B, Graph shows the average movement observed for each residue of the C-spine during the course of the simulations of MLK4-Y330H (orange) compared to MLK4-WT (black). Data is the average of three independent repeats, error bars show ±SEM, * p<0.05.