Table 1.
Summary of associations between inflammatory rheumatic diseases and MICA
| Disease | MICA Variant | Population or Ethnicity | Case/Control or Family | Association (Risk or Protective) |
References |
|---|---|---|---|---|---|
| RA | MICA--A6 | Spanish | 54 families and 211 cases | yes (protective) | [28] |
| RA | MICA--A6 | Caucasian | 90/85 | yes (protective) | [29] |
| RA | MICA--A6 | French Caucasian (FC) and German Caucasian (GC) |
100 families (FC) and 90/182 (GC) | none | [30] |
| RA | MICA--129 | French Caucasian (FC) and German Caucasian (GC) |
100 families (FC) and 90/182 (GC) | yes (unknown) | [30] |
| AS | MICA--A4 | Caucasian | 48/50 | yes (risk) | [32] |
| AS | MICA--A4 | Caucasian | 162/103 | none due to LD with HLA--B27 | [33] |
| AS | MICA--A4 | Sardinia | 82/139 | yes (risk) | [34] |
| AS | MICA--129 met/met | Algerian | 129/760 | yes (risk) | [35] |
| AS | MICA*007:01 | US Caucasian | 1070/1003 | yes (risk) | [36] |
| AS | MICA*007:01 | Chinese Han | 473/536 | yes (risk) | [36] |
| AS | MICA*019 | Chinese Han | 473/536 | yes (risk) | [36] |
| PsA | MICA--A9 | Spanish | 65/177 | yes (risk) | [37] |
| PsA | MICA--A9 | Spanish | 110/110 | yes (risk) | [38] |
| PsA | MICA--A9 | Jewish | 52/73 | yes (risk) | [39] |
| PsA | MICA--A9 | Chinese | 102/210 | none | [40, 41] |
| PsA | MICA--A9 | mixed populations with meta--analysis | 2002 /1933 | yes (risk) | [42] |
| PsA | MICA--129--met/met | Canadian Caucasian | 745/547 | yes (risk) | [44] |
| psoriasis | MICA--A9 | mixed populations with meta--analysis | 2003 /1933 | yes (risk) | [42] |
| psoriasis | MICA--A9 | Chinese | 105/160 | none | [40] |
| psoriasis | MICA--A9 | European | 9247/13589 | none | [46] |
| SLE | MICA--A5 | Italian | 48/158 | yes (risk) | [47] |
| SLE | MICA--A5.1 | Italian | 48/158 | yes (risk) | [47] |
| SLE | MICA--A9 | Italian | 48/158 | yes (protective) | [47] |
| SLE | MICA--A5.1 | Czech | 123/96 | yes (risk) | [48] |
| SLE | MICA129Met;A9 | Japanese | 716/351 | yes (risk) | [50] |
| SLE | any of MICA variants | Spanish | 333/361 | none | [51] |
| BD | MICA--A6 | Japanese | 77/103 | yes (risk) | [54] |
| BD | MICA--A6 | Greek | 38/40 | yes (risk) | [55] |
| BD | MICA--A6 | Korean | 108/204 | yes (risk) | [56] |
| jBD | MICA--A6 | Italian | 18/20 | yes (risk) | [57] |
| BD | MICA--A6 | Iranian | 84/87 | none due to LD with HLA--B51 | [58] |
| BD | MICA--A6 | Spanish | 58/194 | none due to LD with HLA--B51 | [61] |
| BD | MICA--A6 | Italian | 69/130 | none due to LD with HLA--B51 | [62] |
| BD | MICA*009 | European Caucasian | 56/90 | yes (risk) | [66] |
| BD | MICA*019 | Spanish | 42/165 | yes (risk) | [67] |
| CD | MICA--A5.1 | Tunisian | 36/123 | yes (protective) | [81] |
| CD | MICA--A5 | Tunisian | 36/123 | late age of onset | [81] |
| CD | any of MICA variants | Caucasian | 94/154 | none | [90, 91] |
| CD | any of MICA variants | Caucasian | 248/354 | none | [90, 91] |
| UC | MICA--A5.1 | Spanish | 121/116 | yes (protective) | [82] |
| UC | MICA--A5.1 | Chinese | 86/172 and 124/172 | yes (risk) | [86, 87] |
| UC | MICA--A5 | Spanish | 121/116 | worse progression | [82] |
| UC | MICA--A6 | Tunisian | 36/12 | yes (risk) | [81] |
| UC | MICA--A6 | Japanese | 64/236 | none due to LD with HLA--B52 | [89] |
| UC | MICA--A7 | Japanese | 83/132 | yes (risk) | [83] |
| UC | MICA--129--val | Chinese | 272/560 | yes (risk) | [88] |
| UC | MICA*007 | European Caucasian | 141/118 | yes (risk) | [85] |
| UC | any of MICA variants | Caucasian | 94/154 | none | [90, 91] |
| UC | any of MICA variants | Caucasian | 329/354 | none | [90, 91] |
| IBD | MICA--129met/met | Murcians | 88/154 | yes (risk) | [84] |