Table 1.
Beckwith–Wiedemann syndrome/11p overgrowth spectrum clinical features
| Patient # | Hemihypertrophy | Macroglossia | Macrosomia | Ear findings | Umbilical hernia | Hepatomegaly | Tumour | Major features |
|---|---|---|---|---|---|---|---|---|
| Surgery | ||||||||
| 1 | + | + | + | + | − | + | − | 5 |
| 2 | + | − | + | + | + | + | − | 5 |
| 3 | + | − | + | − | − | − | − | 2 |
| 4 | + | + | + | + | + | + | − | 6 |
| 5 | + | − | − | − | − | − | − | 1 |
| 6 | + | + | + | + | − | + | − | 5 |
| 7 | − | − | + | − | − | + | − | 2 |
| 8 | + | + | + | − | − | − | − | 3 |
| 9 | + | − | + | − | − | − | − | 2 |
| 10 | + | + | + | − | − | + | + | 5 |
| 11 | + | − | + | + | + | + | + | 6 |
| 12 | + | − | − | − | − | − | − | 1 |
| 13 | + | − | + | + | + | + | − | 5 |
| 14 | − | − | − | − | + | − | − | 1 |
| Octreotide | ||||||||
| 15 | + | + | + | + | − | + | − | 5 |
| 16 | + | + | + | + | + | + | − | 6 |
| 17 | + | + | + | − | + | + | − | 5 |
| 18 | + | + | + | + | + | + | + | 7 |
| 19 | + | + | + | − | + | + | − | 5 |
| 20 | + | + | + | − | + | + | + | 6 |
| Diazoxide | ||||||||
| 21 | + | + | + | − | + | + | − | 5 |
| 22 | + | + | − | − | − | + | + | 4 |
| 23 | + | − | − | − | + | − | − | 2 |
| 24 | + | + | + | + | + | + | − | 6 |
| 25 | + | − | − | − | + | + | − | 3 |
| 26 | + | − | + | + | + | − | − | 4 |
| 27 | − | + | + | + | + | + | − | 5 |
| 28 | − | + | + | + | + | + | − | 5 |
| 24/28 | 16/28 | 22/28 | 13/28 | 17/28 | 20/28 | 5/28 |