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. 2016 Feb 3;18:40. doi: 10.1186/s13075-016-0934-0

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© Cummiford et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Stronger FC at baseline predicts analgesia. a Patients with higher L M1 (seed in white) − L VL (anatomical region outlined in black) connectivity at baseline had a greater reduction in clinical pain across sham and real transcranial direct current stimulation (tDCS) periods (displayed at p = 0.005). b Stronger L S1 (seed in white) − L anterior insula FC at baseline predicted a better clinical response. c Connectivity between the L VL thalamus (seed in white) and the PAG at baseline also predicted patients who would respond to sham and real tDCS treatment. Data shown are Fisher-transformed r values. M1 primary motor cortex, VL ventral lateral, S1 primary somatosensory cortex, PAG periaqueductal gray, VAS visual analogue scale, L left, R right, FC functional connectivity