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Immunosuppressive agents targeting T cell/antigen-presenting cell interaction and early T cell activation. This depicts agents that inhibit signal 1 and signal 2 in T cell activation. APC, antigen-presenting cell; CNI, calcineurin inhibitor; CTLA4, cytotoxic T lymphocyte–associated protein 4; ICAM, intracellular adhesion molecule 1; LFA-1, lymphocyte function–associated antigen-1; NFAT, nuclear factor of activated T cells; TCR, T cell receptor.
