Fig. 3.

Effect of TUDCA treatment on systemic glucose metabolism and insulin sensitivity in ob/ob mice. (A) Blood glucose concentrations (mg/dl) in the fed state in ob/ob and WT mice, treated with TUDCA or vehicle. (B) Body weights of ob/ob and WT mice treated with TUDCA or vehicle. (C) Plasma insulin concentrations (ng/ml) measured after a 6-hour fast at the onset of experiments and after 30 days of treatment with TUDCA or vehicle. (D) Insulin (2 IU/kg) tolerance and (E) glucose (0.5 g/kg) tolerance tests performed after 15 days of treatment with TUDCA or vehicle. The insulin and glucose tolerance tests were performed on different groups of mice. Data are presented as the means ± SEM, and asterisks indicate statistical significance determined by Student’s t test (*P < 0.05, **P < 0.001).