Fig. 5.

Hyperinsulinemic-euglycemic clamp studies in ob/ob mice treated with PBA or TUDCA. Hyperinsulinemic-euglycemic clamp studies were performed after 20 days of treatment with vehicle, PBA, or TUDCA. (A) Basal hepatic glucose production (HGP). (B) HGP during the clamp. (C) Glucose infusion rates (GIR). (D) Glucose disposal rates (Rd). (E) Glucose uptake into muscle tissue during the clamp. (F) Glucose uptake into white adipose tissue (WAT). (G) Glucose levels during clamp procedure. (H) Glucose infusion rates during the clamp procedure. Data are presented as the means ± SEM, and asterisks indicate statistical significance determined by analysis of variance, post hoc test–Fisher’s Protected Least Significant Difference (*P < 0.05, **P < 0.001).