Figure 1. Effects of the NAA10 p.S37P mutation in Ogden syndrome cells.

Cells expressing the Naa10 S37P variant have a reduced NatA complex formation and a reduced Naa10/NatA catalytic activity. The reduced catalytic activity causes a reduced Nt-acetylation of NatA substrates. Cells expressing the Naa10 S37P variant also have a reduced cell proliferation, a reduced cell contact inhibition and a reduced cell migration.