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. 2015 Sep 27;6(33):34191–34205. doi: 10.18632/oncotarget.5763

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Copyright: © 2015 Kang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. HeLa cells stably overexpressing either the control vector (HeLa/Neo) or Bcl-2 (HeLa/Bcl-2) were treated with different doses of Rac1 inhibitor EHT1864 for 2 hours and the lysates were probed for STAT3^pTyr705, total STAT3, Bcl-2^pSer70, total Bcl-2, Rac1 and β-actin. B. Percentage change in STAT3^pTyr705 levels were predicted upon changes in intracellular superoxide levels in the base cell line as compared to the control cell line. C. HeLa cells stably overexpressing either the control vector (HeLa/Neo) or Bcl-2 (HeLa/Bcl-2) were treated with the Nox inhibitor DPI for 2 hours and the lysates were probed for STAT3^pTyr705, total STAT3, Bcl-2^pSer70, Rac1 and β-actin. D. HeLa cells stably overexpressing Bcl-2 (HeLa/Bcl-2) were lysed 48 hours post transient transfection with control empty vector (EV) or various Rac1 mutants (V12, N17, H103 or K166) and probed for STAT3^pTyr705 & STAT3^pSer727, total STAT3, Bcl-2^pSer70, total Bcl-2, Myc-Tag, Rac1 and β-actin in the whole cell lysates.