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. 2015 Sep 10;6(33):34245–34257. doi: 10.18632/oncotarget.5196

Figure 3. JAK2 mediates LFA-1 affinity triggering and RhoA activation by CXCL12 in B-lymphocytes.

Figure 3

A. KIM127 or B 327A staining; cells were treated for 1 h with vehicle (NT and Control), AG490 100 μM, P1 or P1-TKIP 40 μM, and stimulated with CXCL12 0.5 μM for 120 sec. Mean ± SD. *P < 0.001, versus Control or P1. C. RhoA activation; cells were treated and stimulated as in (A–B). Mean ± SD. *P < 0.001, versus Control or P1. Data are average of n = 10 independent experiments (in duplicate for RhoA activation) using B-cells isolated from 10 different healthy donors.