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. 2015 Sep 10;6(33):34245–34257. doi: 10.18632/oncotarget.5196

Figure 6. JAK2 mediates underflow adhesion, LFA-1 affinity triggering and RhoA activation by CXCL12 in CLL B-lymphocytes.

Figure 6

Underflow adhesion to ICAM-1 A–B or VCAM-1 C–D. Cells were treated for 1 h with vehicle (Control), AG490 100 μM, P1 or P1-TKIP 40 μM. Mean ± SD. *P < 0.01, versus Control; n = 5 (patients samples) independent experiments. E. KIM127 or F 327A staining: cells were treated for 1 h with vehicle (NT and Control), AG490 100 μM, P1 or P1-TKIP 40 μM, and stimulated with CXCL12 0.5 μM for 120 sec. Mean ± SD. *P < 0.001, versus Control or P1; n = 15 (patients samples) independent experiments. G. RhoA activation: cells were treated and stimulated as in (E–F). Mean ± SD. *P < 0.001, versus Control or P1; n = 15 (patients samples) independent experiments in duplicate.