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. 2015 Oct 13;6(33):34258–34275. doi: 10.18632/oncotarget.5545

Figure 9. Proposed model for the mechanisms of arenobufagin-induced G2 arrest in HCC cells.

Figure 9

Arenobufagin directly binds with DNA via intercalation, leading to DSBs and triggering DDR via the ATM/ATR signaling pathway, which subsequently results in G2 phase arrest in HCC cells.