Table 1. Intestinal stem cell signature genes whose levels are upregulated in Ls174T cells stably overexpressing L1 as compared to empty vector-transfected cells.
| Gene symbol | Gene annotation | Gene description | Fold change | p-Value |
|---|---|---|---|---|
| HMGCS2 | NM_005518 | 3-Hydroxy-3-methylglutaryl-coenzyme A synthase 2 (mitochondrial) | 7,108 | 2,62E-59 |
| CLU | NM_001831 | Clusterin | 2,397 | 2,62E-13 |
| PLCE1 | NM_016341 | Phospholipase C, epsilon 1 | 1,874 | 1,57E-06 |
| ISG20L2 | NM_030980 | Interferon stimulated exonuclease gene 20kDa-like 2 | 1,472 | 0,001 |
| MCM2 | NM_004526 | Minichromosome maintenance complex component 2 | 1,441 | 0,001 |
| MCM4 | NM_005914 | Minichromosome maintenance complex component 4 | 1,396 | 0,003 |
| BCL11B | NM_138576 | B-cell CLL/lymphoma 11B (zinc finger protein) | 1,385 | 0,006 |
| PPAT | NM_002703 | Phosphoribosyl pyrophosphate amidotransferase | 1,375 | 0,006 |
| FHDC1 | NM_033393 | FH2 domain containing 1 | 1,347 | 0,021 |
| PAICS | NM_001079525 | Phosphoribosylaminoimidazole succinocarboxamide synthetase | 1,329 | 0,006 |
| CBX2 | NM_005189 | Chromobox homolog 2 | 1,303 | 0,025 |
| MCM6 | NM_005915 | Minichromosome maintenance complex component 6 | 1,295 | 0,02 |
| MCM7 | NM_005916 | Minichromosome maintenance complex component 7 | 1,293 | 0,015 |
| RASA3 | NM_007368 | RAS p21 protein activator 3 | 1,288 | 0,033 |
| CHEK2 | NM_007194 | Checkpoint kinase 2 | 1,278 | 0,038 |
| MSH2 | NM_000251 | MutS homolog 2 | 1,273 | 0,036 |
| DTL | NM_016448 | Denticleless E3 ubiquitin protein ligase homolog (Drosophila) | 1,262 | 0,044 |
| MYO1B | NM_001130158 | Myosin IB | 1,25 | 0,051 |
| CCNB1 | NM_031966 | Cyclin B1 | 1,224 | 0,046 |