Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A. Without Wnt activation, constitutive level of RMRP is expressed. β-catenin and YAP proteins are low in Wnt OFF state due to the degradation in the cytoplasm. B. Upon Wnt activation, β-catenin and YAP protein levels are increased and translocated to the nucleus. Association of β-catenin and YAP to the RMRP promoter in conjunction with DNA binding proteins, TCF and TBX5, lead to the enhanced expression of RMRP.
