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. 2015 Sep 27;6(33):34774–34787. doi: 10.18632/oncotarget.5793

Figure 4. Distribution of HSV genomes to blood and other organs of tumor-free and metastasis-bearing NSG mice.

Figure 4

A., B. NSG mice were inoculated i.v. with MDA-MB-453-EGFP cells, or left untreated. Six weeks later, FM-MSCs were infected ex vivo with R-LM249 by aid of PEG6000. Seven h later they were administered i.v. to tumor-free A. or metastasis-bearing B. mice. The indicated organs were withdrawn at the indicated times after infected cell administration. DNA was extracted and samples were analyzed by qPCR with primers annealing to the HSV genome (HSV) [22]. Results represent the average of 3 mice for each time point ± S.D.