Table 2. Incidence of lung metastases in athymic nude mice treated with R-LM249-infected FM-MSCs.
| Treatmenta | Lung metastases | ||
|---|---|---|---|
| Incidence (%) | Median | Range | |
| Untreated | 13/19 (68%) | 5 | 0 – 157 |
| FM-MSCs | 13/18 (72%) | 9.5 | 0 - >200 |
| R-LM249 FM-MSCs | 3/19* (16%) | 0* | 0 - 31 |
a
Mice received an i.v. injection of SK-OV-3 cells; one week later they received an i.v. injection of R-LM249-infected FM-MSCs (R-LM249 FM-MSCs), uninfected FM-MSCs (FM-MSCs), or vehicle (Untreated). Mice were sacrificed 9 weeks later.
*
Significance of difference versus Untreated and FM-MSCs is p<0.01 (Fisher's Exact test for frequency and Mann–Whitney rank sum test for metastasis number).