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. 2015 Oct 12;6(33):34846–34858. doi: 10.18632/oncotarget.5413

Figure 5. CX-5461 activates MAPK signaling pathway.

Figure 5

A. SEM cells were treated with 250 nM CX-5461 or DMSO for 1 day. Proteome profiler human phospho-kinase array was incubated with equal amount of control or drug treated sample. Results show an increase in pERK (1), pCHK2 (2) and HSP60 (3) signal in CX-5461 treated cells compared to DMSO treated control. B. Increase in pERK signal was confirmed with western blot of CX-5461 treated SEM, NALM-6 and KOPN-8 cells. Adjusted relative density of pERK signal normalized to corresponding DMSO treated control is indicated.