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. 2015 Oct 12;6(33):34846–34858. doi: 10.18632/oncotarget.5413

Figure 6. MEK1/2 inhibitors enhance cytotoxicity of CX-5461.

Figure 6

A. SEM cells were treated with 250 nM CX-5461 alone or 10 μM U-0126 alone or their combination. Western blot shows U-0126 reduced the levels of pERK induced by CX-5461 treatment. B. SEM, KOPN-8 and NALM-6 cells were treated as in (a) and cell viability was measured using trypan blue staining at 55 hours. C. Cell lines were treated as in (a) but with another MEK1/2 inhibitor trametinib (150 nM Ttb). Combination treatment showed reduced viability in all three cell lines compared to single agent treated cells. (b, c) All experiments were repeated three times. Data represents mean +/− S.D.