Table 3. Adverse event in our study compared with the FLAGS study.
| S-1plus cisplatin | 5-FU plus cisplatin | |||||||
|---|---|---|---|---|---|---|---|---|
| Our result (%) | FLAGS Study (%) | Our result (%) | FLAGS Study (%) | |||||
| All | Grade 3/4 | All | Grade 3/4 | All | Grade 3/4 | All | Grade 3/4 | |
| Neutropenia | 68.6 | 36.4 | 28.6 | 18.6 | 55.9 | 13.6 | 47.2 | 40.0 |
| Anemia | 80.2 | 25.6 | 44.0 | 15.7 | 72.0 | 11.9 | 46.1 | 19.3 |
| Leucopenia | 71.9 | 17.6 | 17.5 | 7.3 | 62.7 | 5.9 | 23.0 | 13.8 |
| Thrombocytopenia | 44.6 | 14.1 | 17.7 | 5.4 | 26.3 | 4.2 | 22.8 | 8.5 |
| Diarrhea | 24.0 | 5.8 | 29.2 | 4.8 | 17.8 | 1.7 | 38.4 | 4.5 |
| Vomiting | 43.0 | 4.1 | 48.0 | 7.9 | 42.4 | 5.1 | 55.3 | 9.6 |
| Nausea | 50.4 | 3.3 | 61.6 | 7.5 | 60.2 | 4.2 | 67.3 | 9.6 |
| Anorexia | 38.0 | 2.5 | 31.5 | 6.0 | 41.5 | 3.4 | 34.8 | 5.5 |
| Constipation | 20.7 | 0 | / | / | 22.0 | 0.9 | / | / |
| Abdominal pain | 15.7 | 1.7 | 25.1 | 7.3 | 5.9 | 0 | 22.4 | 5.3 |
| Fatigue | 21.5 | 0 | 39.3 | 12.3 | 22.0 | 0 | 39.4 | 13.2 |
| Abnormal pigmentation | 10.7 | 0 | / | / | 1.7 | 0 | / | / |
| Hypokalemia | 4.1 | 0 | 6.9 | 3.6 | 4.2 | 0.9 | 16.7 | 10.8 |
| Dehydration | / | / | 12.1 | 4.8 | / | / | 15.6 | 7.5 |
| Weight loss | 0.8 | 0 | 28.4 | 4.0 | 0 | 0 | 32.3 | 6.1 |
| Stomatitis | 3.3 | 0.8 | 6.3 | 1.3 | 6.8 | 0.9 | 30.1 | 13.6 |