Table 5. WNT1/FGF3 Targets Increased in Human Breast Cancer Cells in Vivo: Mitochondria and Glycolysis.
| Symbol | Description | Fold-Change | P-value |
|---|---|---|---|
| Mitochondrial-related Proteins/TCA Cycle (26) | |||
| ATP5O | ATP synthase subunit O, mitochondrial | 5.12 | 2.13E-06 |
| ATP5B | ATP synthase subunit beta, mitochondrial | 5.04 | 2.75E-06 |
| ATP5A1 | ATP synthase subunit alpha, mitochondrial | 5.01 | 3.09E-06 |
| COX6A1 | Cytochrome c oxidase subunit 6A, mitochondrial | 4.46 | 2.07E-05 |
| ECHS1 | Enoyl-CoA hydratase, mitochondrial | 4.05 | 8.22E-05 |
| MDH1 | Malate dehydrogenase, cytoplasmic | 3.99 | 9.88E-05 |
| PCK2 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial | 3.88 | 1.43E-04 |
| SCD | Acyl-CoA desaturase | 3.70 | 2.55E-04 |
| HSPA9 | Stress-70 protein, mitochondrial | 3.69 | 2.64E-04 |
| NQO1 | NAD(P)H dehydrogenase [quinone] 1 | 3.49 | 4.81E-04 |
| HSPD1 | 60 kDa heat shock protein, mitochondrial | 3.42 | 5.93E-04 |
| COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 3.39 | 6.61E-04 |
| TUFM | Elongation factor Tu, mitochondrial | 3.38 | 6.74E-04 |
| C21orf33 | ES1 protein homolog, mitochondrial | 3.31 | 8.40E-04 |
| NDUFS1 | Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit | 3.20 | 1.15E-03 |
| IDH1 | Isocitrate dehydrogenase [NADP] 1 | 3.18 | 1.22E-03 |
| OAT | Ornithine aminotransferase, mitochondrial | 3.17 | 1.25E-03 |
| CS | Citrate synthase, mitochondrial | 2.66 | 5.13E-03 |
| AK2 | Adenylate kinase 2, mitochondrial | 2.20 | 1.59E-02 |
| IDH3A | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 2.16 | 1.78E-02 |
| PRKDC | DNA-dependent protein kinase catalytic subunit (maintains mt-DNA copy number) | 2.14 | 1.85E-02 |
| CLPX | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial | 2.11 | 1.96E-02 |
| ABAT | 4-aminobutyrate aminotransferase, mitochondrial | 2.08 | 2.14E-02 |
| ACO2 | Aconitase 2, mitochondrial | 1.83 | 3.64E-02 |
| DUT | Deoxyuridine 5′-triphosphate nucleotidohydrolase, mitochondrial | 1.87 | 3.37E-02 |
| ETFA | Electron transfer flavoprotein subunit alpha, mitochondrial | 1.76 | 4.25E-02 |
| Enzymes Related to Glycolysis, the Pentose Phosphate Pathway, Glycogen, and Amino Acid Synthesis (Serine/Arginine) (4) | |||
| PKM2 | Pyruvate kinase | 3.26 | 9.79E-04 |
| PGK1 | Phosphoglycerate kinase | 2.46 | 8.66E-03 |
| TKT | Transketolase | 2.20 | 1.60E-02 |
| ENO1 | Enolase, alpha | 1.96 | 2.75E-02 |
-Transcriptional profiling data derived from the analysis of N=28 breast cancer patients are shown, high-lighting the levels of fold-upregulation observed in the epithelial cancer cell compartment (relative to the tumor stroma), and corresponding p-values derived from the analysis of these clinical samples.