Table 7. WNT1/FGF3 Targets Increased in Human Breast Cancer Cells in Vivo: Ribosomes and Protein Synthesis.
| Symbol | Description | Fold-Change | P-value |
|---|---|---|---|
| Ribosome-related proteins (8) | |||
| SRPRB | Signal recognition particle receptor subunit beta | 4.68 | 9.97E-06 |
| RPL15 | 60S ribosomal protein L15 | 4.60 | 1.28E-05 |
| RPL13 | 60S ribosomal protein L19 | 4.48 | 1.98E-05 |
| RPL13 | 60S ribosomal protein L13 | 4.48 | 1.98E-05 |
| RPL14 | 60S ribosomal protein L14 | 4.45 | 2.15E-05 |
| RPS5 | 40S ribosomal protein S5 | 4.41 | 2.45E-05 |
| RPL4 | 60S ribosomal protein L4 | 3.05 | 1.79E-03 |
| NPM1 | NPM1 protein | 2.42 | 9.50E-03 |
| Translation initiation factors (3) | |||
| EIF2S1 | Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa | 3.98 | 1.04E-04 |
| EIF3D | Eukaryotic translation initiation factor 3 subunit D | 2.85 | 3.13E-03 |
| EIF5B | Eukaryotic translation initiation factor 5B | 2.58 | 6.29E-03 |
| Elongation factors (4) | |||
| EEF1B2 | Elongation factor 1-beta | 4.08 | 7.56E-05 |
| EEF1G | Elongation factor 1-gamma | 3.71 | 2.44E-04 |
| TUFM | Elongation factor Tu, mitochondrial | 3.38 | 6.74E-04 |
| EEF1D | Elongation factor 1-delta | 2.50 | 7.67E-03 |
| Enzymes for tRNA synthesis (4) | |||
| C22orf28 | tRNA-splicing ligase RtcB homolog | 4.59 | 1.37E-05 |
| EPRS | Bifunctional aminoacyl-tRNA synthetase (Glutamyl-Prolyl-tRNA Synthetase) | 4.06 | 8.10E-05 |
| DARS | Aspartate--tRNA ligase, cytoplasmic | 3.43 | 5.87E-04 |
| WARS | Tryptophan--tRNA ligase, cytoplasmic | 2.48 | 8.17E-03 |
| Protein folding chaperones (heat shock proteins) (11) | |||
| HSP90AB1 | Heat shock protein HSP 90-beta | 4.94 | 4.03E-06 |
| PPIA | Peptidyl-prolyl cis-trans isomerase A | 4.29 | 3.74E-05 |
| CANX | Calnexin | 3.99 | 9.88E-05 |
| PDIA6 | Protein disulfide-isomerase A6 | 3.62 | 3.22E-04 |
| HSPD1 | 60 kDa heat shock protein, mitochondrial | 3.42 | 5.93E-04 |
| PPIB | Peptidyl-prolyl cis-trans isomerase B | 3.28 | 9.25E-04 |
| HSPH1 | Heat shock protein 105 kDa | 3.18 | 1.22E-03 |
| HSPA8 | Heat shock cognate 71 kDa protein | 3.11 | 1.49E-03 |
| PDIA3 | Protein disulfide-isomerase A3 | 2.53 | 7.22E-03 |
| HSP90B1 | Endoplasmin | 2.43 | 9.33E-03 |
| PDIA4 | Protein disulfide-isomerase A4 | 2.13 | 1.89E-02 |
-Transcriptional profiling data derived from the analysis of N=28 breast cancer patients are shown, high-lighting the levels of fold-upregulation observed in the epithelial cancer cell compartment (relative to the tumor stroma), and corresponding p-values derived from the analysis of these clinical samples.