| Wide lamella and lamellipodium at leading edge |
No or little lamella; cell "trails" at trailing edge |
| Lamella containing few microtubules and a dense acto-myosin-rich cortex |
Trails containing a core of microtubule bundles and a dense corona of F-actin |
| Nucleus at the back of the cell |
Nucleus at the front of the cell |
| MTOC towards leading edge |
MTOC towards trailing edge |
| Activation of Rho/ROCK |
De-activation of Rho/ROCK |
| Increased focal adhesions |
Decreased focal adhesions |
| Increased traction forces |
Decreased traction forces |
| Motility depends weakly on MT assembly dynamics |
Migration critically depends on MT assembly/dynamics |
