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. 2015 Oct 2;6(31):30730–30744. doi: 10.18632/oncotarget.5078

Figure 2. Global CpdA effect on the expression of glucocorticoid-responsive genes in epithelial and lymphoid cells.

Figure 2

A. LNCaP-GR cells were treated with vehicle (EtOH), glucocorticoid Dexamethasone (Dex, 1 uM) or CpdA (5 uM) for 8 h; B. Granta-519 cells expressing endogenous GR, were treated with vehicle, Dex (1 uM) or CpdA (1 uM) for 16 h. Total RNA was extracted, and global gene expression changes were evaluated by Illumina DNA arrays (three individual RNA samples/group). Expression changes with fold change > 1.5, and p-value < 0.05 were considered biologically and statistically significant. Effect of CpdA on Dex-regulated genes: down-regulation (black); up-regulation (grey), no change (white).