Table 1. Gene alterations in primary and recurrent GBM according to their molecular subtypes.
Primary glioblastoma | Recurrent glioblastoma | |||||||
---|---|---|---|---|---|---|---|---|
Proneural | Neural | Classical | Mesenchymal | Proneural | Neural | Classical | Mesenchymal | |
No. of patients | 13 | 7 | 32 | 36 | 5 | 2 | 5 | 10 |
IDH 1 mutation | 10 | 0 | 2 | 0 | 4 | 0 | 1 | 1 |
TP53 mutation | 5 | 5 | 14 | 20 | 1 | 1 | 4 | 7 |
EGFR mutation | 4 | 1 | 8 | 10 | 2 | 0 | 1 | 1 |
ATRX mutation | 2 | 2 | 2 | 3 | 0 | 0 | 1 | 3 |