Skip to main content
. 2015 Aug 17;6(31):31030–31038. doi: 10.18632/oncotarget.5208

Figure 1. Overview of transcriptional network involved in the development of drug resistance.

Figure 1

A., ARACNE was used to identify the transcriptional network in approximately 594 ovarian cancer samples obtained from TCGA. B. Regulon extraction using previously defined TFs. C. Expression signatures of genes involved in drug resistance of ovarian cancer cells were obtained using Affymetrix GeneChip Human Gene 1.0 ST oligonucleotide arrays. D. Genes overlapping between regulons in B and gene signatures in C were enriched and statistically analyzed.