Figure 11.

Representative images obtained from the same tumor area that is mainly negative for the expression of Mart-1/Melan A. The morphology of these cells is somewhat different to the use aspect of the melanoma cells with pale cytoplasm, greater nuclei and evident nucleoli. These cells are smaller, with atypical mitosis but the number of cells in proliferative state is similar to the found in areas with positive expression of Mart-1/Melan A and are clearly different tothose that belong to the stroma around the vases, these are smaller and their distribution is not in a cluster. Taking all these characteristic and the negative expression of Mart-1/Melan A into account, we believe that these are less differentiated melanic cells.