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. 2015 Sep 5;6(31):31216–31232. doi: 10.18632/oncotarget.5157

Figure 6. Effect of apigenin on IKKα/β its phosphorylation and NF-ĸB/p65 protein expression in human prostate cancer cells.

Figure 6

A. PC-3 and B. 22Rv1 cells were treated with indicated doses and times with 20 μM apigenin for 16 h and protein expression of NF-ĸB/p65, IKKα, IKKβ and their phosphorylation was determined by Western blot analysis. A significant decrease in IKKα/β phosphorylation, IKKα and NF-ĸB/p65 in dose- and time- dependent fashion was observed. Relative density of bands showing time course change in the protein expression of p-IKKα/β and NF-ĸB/p65 is shown in the right panel. Details are described in ‘materials and methods’ section.