Table 3. ibrutinib inhibitory efficacy for EGFR Y1068/Y1173 auto-phosphorylation in intact cells.
Drug (EC50: nM) Y1068/Y1173 | H1975 | PC-9 | HCC827 | H3255 | A431 |
---|---|---|---|---|---|
ibrutinib | 145/63 | 46/15 | 58/13 | 23/20 | 49/18 |
WZ4002 | 7/4 | 77/19 | 50/36 | 42/38 | 1436/375 |
CO-1686 | 29/7 | 123/10 | 72/36 | 250/63 | > 3000/1200 |
AZD9291 | 6/1 | 25/24 | 22/19 | 17/5 | 818/108 |