Skip to main content
. 2015 Sep 5;6(31):31313–31322. doi: 10.18632/oncotarget.5182

Table 3. ibrutinib inhibitory efficacy for EGFR Y1068/Y1173 auto-phosphorylation in intact cells.

Drug (EC50: nM) Y1068/Y1173 H1975 PC-9 HCC827 H3255 A431
ibrutinib 145/63 46/15 58/13 23/20 49/18
WZ4002 7/4 77/19 50/36 42/38 1436/375
CO-1686 29/7 123/10 72/36 250/63 > 3000/1200
AZD9291 6/1 25/24 22/19 17/5 818/108