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. 2015 Sep 8;6(31):31378–31398. doi: 10.18632/oncotarget.5145

Figure 10. Activation of MET signaling in human skeletal myoblasts blocks their growth and terminal differentiation.

Figure 10

A. Human skeletal myoblasts were transduced with viral vectors encoding GFP and TPR-MET and selected with blasticidin. Expression of TPR-MET transgene at mRNA level was verified by PCR. The picture shows one representative experiment. B. Representative photos show morphology of human myoblasts after 4 passages. Introduction of TPR-MET induces cytotoxicity, blocks myoblasts growth and terminal differentiation. C. TPR-MET myoblasts display decreased expression of late myogenic factors, such as myogenin, myosin heavy chain, myostatin and MEF2A, qPCR, n = 2. *p < 0.05, **p < 0.01. Data in graphs are represented as mean +/− SEM.