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. 2015 Sep 8;6(31):31378–31398. doi: 10.18632/oncotarget.5145

Figure 3. Activation of MET signaling in SMS-CTR ERMS blocks myogenic differentiation of tumors in vivo.

Figure 3

A. Hematoxylin-eosin staining showed anaplastic morphology of tumors formed by SMS-CTR cells expressing TPR-MET four weeks after subcutaneous implantation of the cells to immunodeficient NOD-SCID mice, whereas control tumors were formed by cells resembling muscle fibers. B. Expression of myogenic differentiation markers was evaluated at mRNA level by qPCR in SMS-CTR wild-type cells and in paraffin-embedded specimens from tumors formed by SMS-CTR cells after subcutaneous implantation of the cells, n = 4–5. C. Constitutive activation of MET signaling in SMS-CTR tumors in NOD-SCID mice inhibits myogenin, myostatin and MEF2A level, qPCR, n = 4–5. *p < 0.05, **p < 0.01. Data in graphs are represented as mean +/− SEM.