Skip to main content
. 2015 Oct 2;6(31):31569–31592. doi: 10.18632/oncotarget.5035

Figure 2. Differentially expressed genes in c-Myc transgenic lung and lung tumors.

Figure 2

A. Histology of transgenic lung with pre-cancerous lesions (AHH of BAC-type). The insert represents a 2-fold magnification and depicted are groups of atypical bronchioloalveolar cells with enlarged vesicular nuclei. B. Papillary lung adenocarcinoma (PLAC). The insert represents a 2-fold magnification. Depicted are high columnar tumor cells with vesicular nuclei and prominent nucleoli. When compared to the atypical bronchioloalveolar cells of AHH the nuclei in PLAC are further enlarged. C. Venn Diagram: Number of regulated genes in transgenic lung and c-Myc regulated cell cycle and apoptosis genes in invasive PLAC. Note, only 4 genes are commonly regulated in transgenic lung and PLAC to suggest different activities of wild type and oncogenic c-Myc.