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. 2015 Oct 2;6(31):31569–31592. doi: 10.18632/oncotarget.5035

Figure 4. Master regulatory gene networks in lung tumors of c-Myc transgenic mice.

Figure 4

A. Gata 3 master regulatory network of repressed gene expression. 63% or 15 out of 24 down- regulated genes are part of the GATA3 regulatory network. B. Hspa9 (= mortalin) master regulatory network of induced gene expression. 67% or 18 out of 27 regulated genes are part of the Hspa9 network. The networks were constructed with the GeneXplain platform; the colour coding red, blue and green represent nodes for master regulator, regulated genes and connecting genes, respectively. An activation, inactivation and regulation are denoted by the symbols Inline graphic, respectively.