Table 1. Statistics of differentially expressed genes in SPC/c-Myc-transgenic lung tumors.
| UP-regulated genes | Number of genes containing c-Myc binding sites | ||
|---|---|---|---|
| all up-regulated genes in tumors | 162 | 67 | 41,4% |
| Known direct c-Myc-targets (T) | 32 | 20 | 62,5% |
| relatives of known direct c-Myc-targets (rT) | 15 | 5 | 33,3% |
| Known c-Myc-responsive genes (R) | 16 | 8 | 50% |
| relatives of known c-Myc-responsive genes (rR) | 9 | 2 | 22,2% |
| new c-Myc-responsive genes | 90 | 32 | 35,6% |
| DOWN-regulated genes | Number of genes containing c-Myc binding sites in their promoters | ||
|---|---|---|---|
| all down-regulated genes in tumors | 301 | 71 | 23,6% |
| Known direct c-Myc-targets (T) | 5 | 0 | 0% |
| relatives of known direct c-Myc-targets (rT) | 16 | 3 | 18,8% |
| Known c- Myc- responsive genes (R) | 24 | 6 | 25,0% |
| relatives of known c-Myc-responsive genes (rR) | 17 | 4 | 23,5% |
| new c-Myc responsive genes | 239 | 58 | 24,3% |
A total of 5269 and 4706 genes were expressed in control lung (N=4) and tumors (N=10) using the criteria signal value ≥70 and “present” detection call in Affymetrix microarray analysis. Differentially expressed genes are defined by a fold change ≥3 or ≤-3 and 100% concordance in increase or decrease change calls of tumor samples, respectively. Statistical significance was considered in T-test analysis between sets of small (N=3), middle (N=4) and large size tumors (N=4) at p<0,05.