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. 2015 Sep 30;6(31):31640–31658. doi: 10.18632/oncotarget.5151

Figure 3. Immunhistochemical (IHC) detection of c-Met was performed in specimen of 16 different patients with confirmed SCCOHT.

Figure 3

A. IHC analysis in the primary patient tumor (origin of SCCOHT-1 cells) confirmed c-Met expression at variable levels with predominantly membrane-bound staining. B. An additional pilot series (n = 15) of primary SCCOHT showed microscopically detectable c-Met expression together with the SCCOHT-1 originating tumor predominantly in 6/16 cases. The staining confirmed significant c-Met expression in a subset of SCCOHT and showed striking variability across cases and within individual tumors, suggesting intra- and intertumoral heterogeneity of c-Met expression.