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. 2015 Sep 30;6(31):31640–31658. doi: 10.18632/oncotarget.5151

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Copyright: © 2015 Otte et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. Cell cycle analysis was performed in SCCOHT-1, BIN-67 cells in the absence or presence of different concentrations of the c-Met inhibitors crizotinib and foretinib for 12 h up to 72 h, respectively. Quantification of the different cell cycle phases represent the mean ± s.d. (n = 3). B. SCCOHT-1^GFP, BIN-67^GFP, NIH:OVCAR-3^GFP and SK-OV-3^GFP ovarian cancer cells were incubated with different concentrations of crizotinib and foretinib for 72 h, respectively, and the proliferative capacity was measured by the fluoroscan assay. Analysis of a drug-dose-response to define IC50 concentrations for crizotinib and foretinib was performed using GraphPad Prism-6. For calculation of the drug-dose-response curves, the data were normalized to the cells-only control in culture medium and to the maximal solvent (DMSO) concentration control of the two compounds, respectively.

A. Cell cycle analysis was performed in SCCOHT-1, BIN-67 cells in the absence or presence of different concentrations of the c-Met inhibitors crizotinib and foretinib for 12 h up to 72 h, respectively. Quantification of the different cell cycle phases represent the mean ± s.d. (n = 3). B. SCCOHT-1^GFP, BIN-67^GFP, NIH:OVCAR-3^GFP and SK-OV-3^GFP ovarian cancer cells were incubated with different concentrations of crizotinib and foretinib for 72 h, respectively, and the proliferative capacity was measured by the fluoroscan assay. Analysis of a drug-dose-response to define IC50 concentrations for crizotinib and foretinib was performed using GraphPad Prism-6. For calculation of the drug-dose-response curves, the data were normalized to the cells-only control in culture medium and to the maximal solvent (DMSO) concentration control of the two compounds, respectively.