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. 2015 Sep 10;6(31):31805–31819. doi: 10.18632/oncotarget.5567

Figure 3. Anti-arthritic effect of DMY in collagen-II induced arthritis (CIA) rats.

Figure 3

A. DMY dose-dependently reduced the arthritic score of CIA rats. B. DMY dose-dependently ameliorated the hind paw swelling of CIA rats. C. DMY suppressed the nuclear translocation of NF-κB p65 in the knee synovial tissues of CIA rat. The bar chart represents the quantitation of Western blots resulting from three different animals within the same treatment groups. D. DMY did not impair the organ indexes of CIA rats. E. Effect of DMY on the body weight change of CIA rats. Six groups of rats were treated daily with DMY at 50 (♦) and 100 mg/kg (■), MTX at 3.75 mg/kg (▲), DEX at 0.1 mg/kg (+), indomethacin at 1 mg/kg (●) or vehicle (x) from day 13 after arthritis induction until day 30. All of the hind paw volumes (mL), arthritic scores and body weights were determined daily, while the organ indexes (spleen or thymus weight over body weight) were calculated for each CIA rat at the end of the experiment. The nuclear protein lysates from the knee synovial tissues of DMY-treated rats were prepared for Western blotting analysis using the antibody against p65. Data are expressed as means ± SEM (n = 7-8). *p < 0.05, ** p < 0.01 compared to vehicle-treated CIA rats.