Figure 2. Hierarchical clustering of 12 samples according to their nucleotide context-specific, exonic, and somatic mutation rates in the exome sequencing screen.

Mutation spectra in each sample were scaled. Each row represents a sample, and each column represents 1 of 96 strand-collapsed trinucleotide context mutation signatures. Top bar, single-nucleotide context mutational signature; left bar, cluster membership; right gradient, mutation rate scale. “-1”: first tumor, “-2”: second tumor.