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. 2015 Sep 11;6(31):32027–32038. doi: 10.18632/oncotarget.5184

Figure 5. HER2 pathway analysis.

Figure 5

A. ERBB2 copy number and gene expression of twenty seven metastatic breast cancer patients. ERBB2 gene expression is significantly higher in patients with increased copy number. Patients with ERBB2 mutation is red colored. B. Averaged mRNA expression of genes in the PID ERBB2 ERBB3 pathway is not associated with ERBB2 amplification. C. Among eleven patients with ERBB2 amplification, pathway score is significantly different between patients with ERBB2 mutation and patients without ERBB2 mutation (P-value = 0.0413). D. ERBB2 amplified and mutated samples yield less expression of GRB2 and pathway level gene expression than ERBB2 amplified and wild.