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. 2015 Sep 11;6(31):32115–32137. doi: 10.18632/oncotarget.5617

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Copyright: © 2015 Vos et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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I. Chromosomal distribution of miRNAs differentially expressed between normal tissue and cancers of BRCA1 carriers. II. Chromosomal distribution of miRNAs differentially expressed between normal tissue and cancers of BRCA2 carriers. All differentially expressed miRNAs from both comparisons with fold change ≥ │1.5│and false discovery rate < 0.05 and known exact chromosomal location are presented. Within chromosomes a mixture of up- and down-regulated miRNAs can be seen. Several hotspots (≥ 4 miRNAs at the same locus) can be seen, in which the miRNAs show a similar direction of deregulation. The miRNA locations partly overlap with known hotspots of chromosomal instability in BRCA1- and BRCA2-associated carcinomas and fragile sites in the genome, in which miRNAs are often located.

I. Chromosomal distribution of miRNAs differentially expressed between normal tissue and cancers of BRCA1 carriers. II. Chromosomal distribution of miRNAs differentially expressed between normal tissue and cancers of BRCA2 carriers. All differentially expressed miRNAs from both comparisons with fold change ≥ │1.5│and false discovery rate < 0.05 and known exact chromosomal location are presented. Within chromosomes a mixture of up- and down-regulated miRNAs can be seen. Several hotspots (≥ 4 miRNAs at the same locus) can be seen, in which the miRNAs show a similar direction of deregulation. The miRNA locations partly overlap with known hotspots of chromosomal instability in BRCA1- and BRCA2-associated carcinomas and fragile sites in the genome, in which miRNAs are often located.