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. 2015 Aug 22;6(31):32177–32192. doi: 10.18632/oncotarget.4867

Figure 6. GOLPH3 may as a promising therapeutic target for bladder cancer in vivo.

Figure 6

A. Knockdown of GOLPH3 by the intratumoral injection of siRNA inhibits the growth of T24-derived xenografts in nude mice. Top, macrographic image showing that the tumor size in the GOLPH3 siRNA group was markedly smaller on the 45th day after tumor cells inoculation than that of the groups injected with PBS and control siRNA; middle, growth curves of the tumor xenografts; bottom, the final tumor weights of the GOLPH3 siRNA group were decreased compared with that of the PBS and negative control siRNA groups. Intratumoral injection of GOLPH3 siRNA inhibited the protein expression of GOLPH3, p-mTOR and Ki67 as determined by western blotting B. and IHC C. analysis in T24 cell derived xenografts.