Table 3. RAD51 foci pooled data.
| Treatment | RAD51 foci/cell | |
|---|---|---|
| M059J | Fus-1 | |
| Control | 1.36 ± 0.15 | 2.27 ±0.28 |
| 10 μM VE-821 | 0.85 ± 0.11 (p = 0.007) | 1.16 ± 0.16 (p=0.0008) |
| IR + 6 hr control | 8.37 ± 0.69 | 7.72 ± 0.58 |
| IR + 6 hr 1 μM VE-821 | 8.01 ± 0.61 (p = 0.69, NS) | 5.18 ± 0.47 (p=0.0007) |
| IR + 24 hr control | 22.94 ± 1.09 | 6.72 ± 0.69 |
| IR + 24 hr 1 μM VE-821 | 9.6 ± 0.82 (p<0.0001) | 2.02 ± 0.84 (p<0.0001) |
Data are mean and standard deviation from 2 or more independent experiments where > 100 nuclei were evaluated. Significance is given for the effect of VE-821 by comparison with control or contemporaneously irradiated cells in the absence of VE-821