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. 2015 Sep 28;6(32):32439–32455. doi: 10.18632/oncotarget.5857

Figure 5. Bortezomib modulates Notch target genes in spleens and lymph nodes of tumor-bearing mice.

Figure 5

Splenocytes and LN cells were harvested 4 h after bortezomib (1 mg/kg body weight) treatment in Balb/c mice established with 14-day subcutaneous tumors. Expression of mRNA is shown for Notch target genes Hes1, Hey1 and Deltex1 in splenocytes and lymph node cells of 4T1HA A., RencaHA B., and D459 C. tumor-bearing mice. Data are expressed as mean ± S.E.M; n = 12 mice, each group; *p < 0.05 saline versus BZB, @p < 0.05 saline versus tumor, #p < 0.05 tumor versus tumor + BZB (ANOVA, one-way). Statistical analysis was based on three individual experiments.