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. 2015 Sep 28;6(32):32439–32455. doi: 10.18632/oncotarget.5857

Figure 8. Bortezomib upregulates the expression of NICD and its downstream target Hes1 in CD8+ T cells.

Figure 8

CD8+ T cells purified from pooled cells of spleen and LN from naïve Balb/c mice were treated with 10 or 20 nM BZB for 4 h. Their nuclear and cytoplasmic extracts were analyzed for cleaved Notch intracellular domain (NICD) expression A., and total protein extract was analyzed for Hes1 expression B. by Western blots. The values represent the densitometric quantification of the immunoblots. GAPDH and Histone H3 were used as loading controls.